| CAS | 135374-80-0 |
| Sequence | H-Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-Lys-Gln-Ala-His-His-Ser-Asn-Val-Leu-Gln-Thr-Ser-Val-Gln-Thr-Thr-Ala-Thr-Phe-Thr-Ser-Met-Asp-Thr-Ser-Gln-Leu-Pro-Gly-Asn-Ser-Val-Phe-Lys-Glu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2 (Disulfide bonds between Cys1 and Cys5/Cys14 and Cys51) |
| Sequence Single | CDATCQFRKAIDDCQKQAHHSNVLQTSVQTTATFTSMDTSQLPGNSVFKECMKQKKKEFKA-NH2 |
| Molecular Formula | C291H466N86O94S6 |
| Molecular Weight | 6865.82 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases |
| Description | Maxadilan, isolated from the salivary gland of the sand fly Lutzomyia longipalpis, is a potent vasodilator. Maxadilan specifically and potently activates the mammalian PAC1 receptor, one of the three receptors for PACAP. |
| References | 1. Inhibition of the action of sex steroids by gonadotropin-releasing hormone (GnRH) agonists: a new biological effect. K.Sundaram et al., Life Sci., 28, 83 (1981) 2. Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons. I.Tatsuno et al., Brain Res., 889, 138 (2001) 3. The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor. M.B.P.Soares et al., J. Immunol., 160, 1811 (1998) 4. Maxadilan. Cloning and functional expression of the gene encoding this potent vasodilator peptide. E.A.Lerner and C.B.Shoemaker, J. Biol. Chem., 267, 1062 (1992) |