| CAS | 860790-38-1 |
| Sequence | H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 |
| Sequence Single | GWTLNSAGYLLGPQPPGFSPFR-NH2 |
| Molecular Formula | C112H161N29O28 |
| Molecular Weight | 2361.68 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | M617 is a selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). M617 enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain. |
| References | 1. Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. Mazarati et al (2006). J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066 2. Activation of peripheral galanin receptors: differential effects on nociception. Jimenez-Andrade et al (2006). Pharmacol.Biochem.Behav. 85 273 PMID: 16996122 3. A galanin receptor subtype 1 specific agonist. Lundstrom et al (2005). Int.J.Pept.Res.Ther. 11 17 4. Central injection of GalR1 agonist M617 facilitates GLUT4 expression in cardiac muscle of type 2 diabetic rats. Fang P, et al. Exp Gerontol. 2015;65:85-89. |