| CAS | 1802078-42-7 |
| Sequence | H-Lys(Dabsyl)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gln-Lucifer Yellow |
| Sequence Single | K(Dabsyl)-SEVNLDAEFRQ-Lucifer Yellow |
| Molecular Formula | C89H122N24O31S3 |
| Molecular Weight | 2120.29 |
| Synonyms | Lys(Dabsyl)-(Asn670,Leu671)-APP770 (667-676)-Gln-Lucifer Yellow |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Lys(Dabsyl)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)-Gln-Lucifer Yellow also called Lys(Dabsyl)-(Asn670,Leu671)-APP770 (667-676)-Gln-Lucifer Yellow, is a highly selective substrate for measuring BACE1 (Km = 9 µM, kcat = 0.02 s-1) and BACE2 activity. In this fluorescence resonance energy transfer (FRET) substrate the fluorescent group Lucifer Yellow is efficiently quenched by Dabsyl (4-(4-Dimethylaminophenylazo)benzenesulfonyl). Enzymatic cleavage can be assayed by detecting the increase in fluorescence emission at 520 nm using an excitation wavelength of 430 nm. |
Lys(Dabsyl)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)-Gln-Lucifer Yellow
CAS No.: 1802078-42-7
Lys(Dabsyl)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)-Gln-Lucifer Yellow also called Lys(Dabsyl)-(Asn
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