(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676) Secretase Inhibitors and Substrates Catalog

CAS	186142-28-9
Sequence	H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-OH
Sequence Single	SEVNLDAEFR
Molecular Formula	C50H78N14O19
Molecular Weight	1179.25
Synonyms	(Asn670,Leu671)-APP770 (667-676), APP770 (667-676) Swedish Mutation
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Alzheimer’s Disease
Description	(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676) also called (Asn670,Leu671)-APP770 (667-676), APP770 (667-676) Swedish Mutation, is a peptide substrate with the seuqnce of SEVNLDAEFR. It corresponds to the ‘Swedish’ Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.
References	1. Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants. R.Ortiz-Castro et al., Proc. Natl. Acad. Sci. USA, 108, 7253 (2011) 2. Identification of beta-secretase-like activity using a mass spectrometry-based assay system. F.Grüninger-Leitch et al., Nat. Biotechnol., 18, 66 (2000) 3. Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity. R.Yan et al., Nature, 402, 533 (1999) 4. Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. R.Vassar et al., Science, 286, 735 (1999)

PeptideDB