| CAS | 52434-75-0 |
| Sequence | Pyr-His-Trp-Ser-Tyr-OH |
| Sequence Single | pEHWSY |
| Molecular Formula | C34H38N8O9 |
| Molecular Weight | 702.72 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | According to Wu et al., LHRH (1-5) (free acid) is a metabolite of GnRH, it could be involved in the regulation of the synthesis, secretion, and functions of the native hormone. Furthermore, GnRH-(1-5) could be involved in regulating cellular migration. |
| References | 1. Presence of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine in fermentations of Penicillium chrysogenum. P.Adriaens et al., Antimicrob. Agents Chemother., 8, 638 (1975) 2. A biological role for the gonadotrophin-releasing hormone (GnRH) metabolite, GnRH-(1-5). T.J.Wu et al., J. Neuroendocrinol., 21, 293 (2009) 3. Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5). T.J.Wu et al., Endocrinology, 146, 280 (2005) 4. Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases. J.R.McDermott et al., Peptides, 4, 25 (1983) 5. The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor. D.O.Larco et al., Front. Endocrinol., 4, 83 (2013) 6. Evidence for a two-step mechanism of gonadotropin-releasing hormone metabolism by prolyl endopeptidase and metalloendopeptidase EC 3.4.24.15 in ovine hypothalamic extracts. R.A.Lew et al., J. Biol. Chem., 269, 12626 (1994) |