| CAS | 132699-73-1 |
| Sequence | H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| Sequence Single | YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2 |
| Molecular Formula | C189H284N54O56S |
| Molecular Weight | 4240.73 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | (Leu31,Pro34)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist. (Leu31,Pro34)-Neuropeptide Y (human, rat) also activates Y4, Y5. (Leu31,Pro34)-Neuropeptide Y (human, rat) can increase blood pressure in anesthetized rats and increases food intake. |
| References | 1. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide’s effect. B.G.Stanley et al., Peptides, 13, 581 (1992) 2. Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y? J.B.Buckwalter et al., Am. J. Physiol. Heart Circ. Physiol., 287, H144 (2004) 3. Tissue-specific regulation of fat cell lipolysis by NPY in 6-OHDA-treated rats. M.Labelle et al., Peptides, 18, 801 (1997) 4. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. J Fuhlendorff, et al. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. 5. 2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. K McCrea, et al. Regul Pept. 2000 Feb 8;87(1-3):47-58. 6. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. A Kask, et al. Br J Pharmacol. 1998 Aug;124(7):1507-15. |
(Leu31,Pro34)-Neuropeptide Y (human, rat)
CAS No.: 132699-73-1
(Leu31,Pro34)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist. (Leu31,Pro34)-Neuropeptide Y
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