| CAS | 800379-47-9 |
| Sequence | Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2 |
| Sequence Single | Ac-KLDLKLDLKLDL-NH2 |
| Molecular Formula | C68H122N16O19 |
| Molecular Weight | 1467.79 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cell Culture|Regenerative Medicine |
| Description | KLD12 is a 12-residue self-assembling peptide that can enhance chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair. |
| References | 1. A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes. V.G.Brichard et al., Eur. J. Immunol., 26, 224 (1996) 2. Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. A.L.Sieminski et al., J. Biomed. Mater. Res. A, 87, 494 (2008) 3. Biocompatibility of KLD-12 peptide hydrogel as a scaffold in tissue engineering of intervertebral discs in rabbits. J.Sun et al., J. Huazhong Univ. Sci. Technolog. Med. Sci., 30, 173 (2010) 4. Self-assembling peptide nanofibers coupled with neuropeptide substance P for bone tissue engineering. S.H.Kim et al., Tissue Eng. Part A., 21, 1237 (2015) 5. Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds. J.D.Kisiday et al., Tissue Eng., 11, 141 (2005) 6. Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. P.W.Kopesky et al., Tissue Eng. Part A., 16, 465 (2010) 7. Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Tripathi JK, et, al. Biomaterials. 2015 Jul;56:92-103. 8. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Kisiday J, et, al. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001. |