| CAS | 56767-30-7 |
| Sequence | H-Thr-Pro-Arg-Lys-OH |
| Sequence Single | TPRK |
| Molecular Formula | C21H40N8O6 |
| Molecular Weight | 500.6 |
| Synonyms | Contraceptive Tetrapeptide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Kentsin also called Contraceptive Tetrapeptide, was first isolated from the oviductal lumen of progravid female hamsters. Kentsin shows opioid-like activity without binding to opioid receptors. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. |
| References | 1. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Fox DA, et al. Peptides. 1987 Jul-Aug;8(4):613-8. 2. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. Suk WA, et al. J Gen Virol. 1981 Jan;52(Pt 1):189-94. 3. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Bueno L, et al. Eur J Pharmacol. 1985 Aug 7;114(1):67-70. 4. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Buéno L, et al. Life Sci. 1986 Jul 14;39(2):141-6. 5. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Wieczorek Z, et al. Peptides. 1994;15(2):215-21. |