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Insulin (human) recombinant expressed in yeast

CAS No.: 11061-68-0

Insulin (human) recombinant expressed in yeast is an endogenous insulin receptor agonist (Ki = 4.85 nM). Insulin (human)
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CAS 11061-68-0
Sequence H-Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn-OH H-Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr-OH* (Disulfide bridge between 6 - 11, 7 -7*, 20 - 19*)
Sequence Single GIVEQCCTSICSLYQLENYCN FVNQHLCGSHLVEALYLVCGERGFFYTPKT*(Disulfide bridge between 6 - 11, 7 -7*, 20 - 19*)
Molecular Formula C257H383N65O77S6
Molecular Weight 5807.57
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Description Insulin (human) recombinant expressed in yeast is an endogenous insulin receptor agonist (Ki = 4.85 nM). Insulin (human) recombinant expressed in yeast decreases plasma glucose levels, proteolysis, lipolysis and gluconeogenesis and increases glycogen and fatty acid synthesis in vivo.
References 1.  Age dependent changes of Ins receptors in rat tissues. Torlinska et al (2000). J.Physiol.Pharmacol. 51 871 PMID: 11220495 2.  The binding characteristics of Ins-MTX to Ins receptor. Ou et al (2001). Hua.Xi.Yi.Ke.Da.Xue.Xue.Bao. 32 538 PMID: 12528542 3.  The molecular basis of Ins-stimulated glucose uptake: signalling, trafficking and potential drug targets. Leney and Tavare (2009). J.Endocrinol. 203 1 PMID: 19389739