| CAS | 1620813-53-7 |
| Sequence | H-D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe-OH |
| Sequence Single | D-(NYSKPTDRQYHF) |
| Molecular Formula | C70H98N20O21 |
| Molecular Weight | 1555.67 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | (D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. (D)-PPA 1 binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. (D)-PPA 1 inhibits tumor growth and prolongs survival time of mice in vivo. |
| References | 1. Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Chang et al (2015). Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671 |