| CAS | 138559-60-1 |
| Sequence | Ac-Arg-Arg-Trp-Trp-Cys-Arg-NH2 |
| Sequence Single | Ac-RRWWCR-NH2 |
| Molecular Formula | C45H66N18O7S |
| Molecular Weight | 1003.2 |
| Synonyms | Antileukinate |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cytokines/Chemokines & their Receptors |
| Description | IL-8 Inhibitor also called antileukinate, inhibits the specific binding of 125I-labeled IL-8 to neutrophils with an apparent Ki = 10 µM. Antileukinate also significantly suppresses neutrophil chemotaxis induced by 10 nM IL-8 at a concentration of 50 µM. The inhibition is specific for IL-8. Antileukinate can be used for the research of acute inflammation and injury. |
| References | 1. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Madhav Bhatia, et al. Regul Pept. 2007 Jan 10;138(1):40-8. 2. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Yuji Fukuno, et al. Cytokine. 2003 Jun 7;22(5):116-25. 3. Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute lung injury in mice. S HayashiY, et al. Lung. 2002;180(6):339-48. |