| CAS | 158040-83-6 |
| Sequence | H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH |
| Sequence Single | AYC(Acm)RDGKIGPPKLDIRKEEKQI |
| Molecular Formula | C115H194N34O34S |
| Molecular Weight | 2629.08 |
| Synonyms | (Tyr121,Cys(Acm)122)-IFN-γ Receptor (120-141) (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | IFN-γ Antagonist also callled (Tyr121,Cys(Acm)122)-IFN-γ Receptor (120-141) (human), is a peptide derived from the ligand binding site of the human γ-interferon (IFN-γ) receptor. It is an antagonist of human IFN-γ. It inhibited human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC50 of 35 µM. Immobilized peptide specifically bound recombinant human IFN-γ. Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide. |
| References | 1. Melittin: a membrane-active peptide with diverse functions. H.Raghuraman and A. Chattopadhyay, Biosci. Rep., 27, 189 (2007) |