| CAS | 1356390-47-0 |
| Sequence | H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bonds between Cys7 and Cys23/Cys10 and Cys13/Cys11 and Cys19/Cys14 and Cys22) |
| Sequence Single | DTHFPICIFCCGCCHRSKCGMCCKT |
| Molecular Formula | C113H170N34O31S9 |
| Molecular Weight | 2789.4 |
| Synonyms | LEAP-1 (human), Hepc25 (human), Liver-Expressed Antimicrobial Peptide (human), PLTR (human), Putative Liver Tumor Regressor (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Antimicrobial & Antiviral Peptides|Hematology |
| Description | Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity. Former CAS-number 342790-21-0. |
| References | 1. Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2). F.Bono et al., Biochem. Biophys. Res. Commun., 241, 762 (1997) 2. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. E.Nemeth et al., Blood, 107, 328 (2006) 3. Hepcidin and iron-loading anemias. E.Nemeth and T.Ganz, Haematologica, 91, 727 (2006) 4. Hepcidin: from discovery to differential diagnosis. E.Kenma et al., Haematologica, 93, 90 (2008) 5. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. A.Krause et al., FEBS Lett., 480, 147 (2000) 6. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. H.N.Hunter et al., J. Biol. Chem., 277, 37597 (2002) 7. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. T.Ganz, Blood, 102, 783 (2003) 8. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. R.E.Fleming and W.S.Sly, Proc. Natl. Acad. Sci. USA, 98, 8160 (2001) |