| CAS | 17355-18-9 |
| Sequence | H-Phe-Tyr-OH |
| Sequence Single | FY |
| Molecular Formula | C18H20N2O4 |
| Molecular Weight | 328.37 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Di- and Tripeptides |
| Description | H-Phe-Tyr-OH ia a dipeptide with an inhibitory effect on the excitability of the TAN. H-Phe-Tyr-OH is one of the ACE-inhibitory dipeptides found in fermented milk. Administration of the dipeptide reduced blood pressure in spontaneously hypertensive rats. |
| References | 1. Long-Range Effects in Oligopeptides. A Theoretical Study of the β-Sheet Structure of Glyn (n = 2-10). V.Horvath et al., J. Phys. Chem., 108, 6869 (2004) 2. Current(I)-voltage(V) relationships of the neuromembrane of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac) in the presence of an inhibitory tripeptide, L-Lys-L-Phe-L-Tyr. H.Takeuchi and H.Tamura, Experientia, 34, 1052 (1978) 3. Inhibitory effect of tripeptides containing L-Phe-L-Tyr on neuronal excitability. H.Takeuchi et al., Eur. J. Pharmacol., 54, 393 (1979) 4. Inhibitory effects of aromatic oligopeptides on the excitability of identifiable giant neurones of an African giant snail (Achatina fulica Férussac). H.Takeuchi et al., Arch. Int. Pharmacodyn. Ther., 237, 149 (1979) 5. Effects of some oligopeptides, consisting of aromatic amino acids, on the excitability of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac). H.Takeuchi and A.Sakai, Experientia, 33, 1348 (1977) |