| CAS | 67368-29-0 |
| Sequence | H-Met-Arg-Phe-Ala-OH |
| Sequence Single | MRFA |
| Molecular Formula | C23H37N7O5S |
| Molecular Weight | 523.66 |
| Synonyms | MRFA |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Hematology |
| Description | H-Met-Arg-Phe-Ala-OH also called MRFA, is used as a calibration standard in mass spectrometry (ESI). Miao et al. studied Pt(II) complexes of the tetrapeptide by mass spectrometric methods. H-Met-Arg-Phe-Ala-OH has been shown to be a competitive inhibitor of an enkephalin-generating endopeptidase isolated from rat brain. H-Met-Arg-Phe-Ala-OH is a substrate for dipeptidyl peptidase III from human erythrocytes and for snapalysin. |
| References | 1. FMRFamide-related peptides from the kidney of the snail, Helisoma trivolvis. K.P.Madrid et al., Peptides, 15, 31 (1994) 2. Extracellular metalloendopeptidase of Streptomyces rimosus. L.Vitale et al., Arch. Microbiol., 185, 183 (2006) 3. Brain endopeptidase generates enkephalin from striatal precursors. M.Knight et al., Peptides, 3, 461 (1982) 4. A reliable method for the amino acid sequence determination in tetrapeptides: A study on the positive and negative ion tandem mass spectra of tetrapeptides. W.Kulik and W.Heerma, Biol. Mass Spectrom., 20, 553 (1991) 5. Dipeptidyl peptidase III from human erythrocytes. M.Abramic et al., Biol. Chem. Hoppe-Seyler, 369, 29 (1988) |