| CAS | 172546-75-7 |
| Sequence | H-His-Cys-Lys-Phe-Trp-Trp-OH |
| Sequence Single | HCKFWW |
| Molecular Formula | C46H55N11O7S |
| Molecular Weight | 906.08 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Infectious Disease|Virology |
| Description | H-His-Cys-Lys-Phe-Trp-Trp-OH also called HCKFWW, is a potent inhibitor of the HIV-encoded integrase (IN), the enzyme responsible for the integration of HIV DNA into the human genome. H-His-Cys-Lys-Phe-Trp-Trp-OH inhibits IN-mediated 3’processing and integration with an IC50 of 2 µM. The peptide is also active on IN proteins from other retroviruses such as HIV-2, feline immunodeficiency virus and Moloney murine leukemia virus. It was also found to inhibit the disintegration reaction, suggesting that this hexapeptide acts at or near the catalytic site of IN. |