| CAS | 7451-76-5 |
| Sequence | H-Gly-Gly-His-OH |
| Sequence Single | GGH |
| Molecular Formula | C10H15N5O4 |
| Molecular Weight | 269.26 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Di- and Tripeptides |
| Description | H-Gly-Gly-His-OH also called GGH, is a Cu(II) and Ni(II)-binding tripeptide.The Ni(II) complex of GGH was shown by Brown et al. to mediate protein crosslinking by oxidants. GGH has been used in biosensors for the electrochemical detection of Cu(II) ions. |
| References | 1. Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Y.Saito et al., Biosci. Biotechnol. Biochem., 58, 1767 (1994) 2. Sub-ppt detection limits for copper ions with Gly-Gly-His modified electrodes. W.Yang et al., Chem. Commun., 1982 (2001) 3. Exploring the use of the tripeptide Gly-Gly-his as a selective recognition element for the fabrication of electrochemical copper sensors. W.Yang et al., Analyst, 128, 712 (2003) 4. Highly specific oxidative cross-linking of proteins mediated by a nickel-peptide complex. K.C.Brown et al., Biochemistry, 34, 4733 (1995) 5. Oxidative DNA damage induced by autoxidation of microquantities of S(IV) in the presence of Ni(II)-Gly-Gly-His. M.V.Alipázaga et al., Dalton Trans., 3738 (2005) 6. Synthesis and antitumor properties of an anthraquinone bisubstituted by the copper chelating peptide Gly-Gly-L-His. E.Morier-Teissier et al., J. Med. Chem., 36, 2084 (1993) 7. Electrochemical analysis of copper ion using a Gly-Gly-His tripeptide modified poly(3-thiopheneacetic acid) biosensor. M.Lin et al., Biosens. Bioelectron., 25, 28 (2009) |