| CAS | 111543-77-2 |
| Sequence | H-Asp-Ala-His-Lys-OH |
| Sequence Single | DAHK |
| Molecular Formula | C19H31N7O7 |
| Molecular Weight | 469.5 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Apoptosis & Necrosis|Cardiovascular System & Diseases |
| Description | The tetrapeptide H-Asp-Ala-His-Lys-OH, also called DAHK, corresponding to the N-terminal sequence of human serum albumin forms a tight binding site for Cu(II) ions. DAHK inhibits Cu(II)-induced oxidative DNA double strand breaks. DAHK is as effective as HSA in preventing neuronal death induced by CuCl2/ascorbic acid. DAHK may be an effective, small-molecular-weight alternative to HSA as a therapeutic agent for stroke. |
| References | 1. Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors. D.M.Segal et al., Biochemistry, 10, 3728 (1971) |