H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH Protein Kinase Related Peptides Catalog

CAS	147612-86-0
Sequence	H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH
Sequence Single	EPQ(p)YEEIPIYL
Molecular Formula	C66H97N12O24P
Molecular Weight	1473.54
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Protein-Tyrosine Kinases\|Virology
Description	H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH is a phosphopeptide derived from the hamster polyoma middle-T antigen. It binds with high affinity and specificity to the Src homology-2 (SH2) domains of the protein tyrosine kinases p56 lck and p60 src. The side chains of residues pY (phosphotyrosine) and Ile at position pY+3 were shown to occupy deep binding pockets of either SH2 domain surface.
References	1. The phosphopeptide-binding specificity of Src family SH2 domains. G Payne, et al. Chem Biol. 1994 Oct;1(2):99-105. 2. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. T D Mulhern, et al. Structure. 1997 Oct 15;5(10):1313-23.

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