H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH Renin Inhibitors and Substrates Catalog

CAS	104180-23-6
Sequence	H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH
Sequence Single	DRVYIHPFHLVIHN
Molecular Formula	C83H122N24O19
Molecular Weight	1760.03
Synonyms	Tetradecapeptide Renin Substrate (human), Angiotensinogen (1-14) (human), Preangiotensinogen (1-14) (human)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cardiovascular System & Diseases
Description	H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH also called Tetradecapeptide Renin Substrate (human), Angiotensinogen (1-14) (human), Preangiotensinogen (1-14) (human), is a renin substrate. It corresponds to the N-terminal tetradecapeptide of human angiotensinogen. Renin cleavage yields Val-Ile-His-Asn and angiotensin I.
References	1. Structure and functions of angiotensinogen. Lu H, et al. Hypertens Res. 2016 Jul;39(7):492-500. 2. The amino-acid residues on the C-terminal side of the cleavage site of angiotensinogeninfluence the species specificity of reaction with renin. Burton J, et al. Biochim Biophys Acta. 1988 Jan 4;952(1):8-12.

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