| CAS | 2418-69-1 |
| Sequence | H-Arg-Pro-OH |
| Sequence Single | RP |
| Molecular Formula | C11H21N5O3 |
| Molecular Weight | 271.32 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Di- and Tripeptides |
| Description | H-Arg-Pro-OH is the dipeptide corresponding to the N-terminal sequence of substance P. During SP metabolism, H-Arg-Pro-OH and H-Lys-Pro-OH are split off by post-proline dipeptidyl aminopeptidase (PPDAP), an enzyme expressed in the brain. |
| References | 1. Action of serine carboxypeptidases on endopeptidase substrates, peptide-4-methyl-coumaryl-7-amides. S.Kunugi et al., Eur. J. Biochem., 153, 37 (1985) 2. Post-proline dipeptidyl-aminopeptidase from synaptosomal membranes of guinea-pig brain. A possible role for this activity in the hydrolysis of His-ProNH2, arising from the action of synaptosomal membrane pyroglutamate aminopeptidase on thyroliberin. B.O’Connor and G.O’Cuinn, Eur. J. Biochem., 154, 329 (1986) 3. Separation of two dipeptidyl aminopeptidases in the human brain. T.Kato et al., J. Neurochem., 34, 602 (1980) |