| CAS | 183200-12-6 |
| Sequence | H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bonds between Cys4 and Cys12/Cys7 and Cys15) |
| Sequence Single | PGTCEICAYAACTGC |
| Molecular Formula | C58H87N15O21S4 |
| Molecular Weight | 1458.68 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Gastrointestinal Research |
| Description | Guanylin (human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin (human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism. |
| References | 1. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. A.Asakawa et al., Gut, 52, 947 (2003) 2. Human guanylin: cDNA isolation, structure, and activity. R.C.Wiegand et al., FEBS Lett., 311, 150 (1992) 3. Guanylin and related peptides. J.Beltowski, J. Physiol. Pharmacol., 52, 351 (2001) 4. Precursor structure, expression, and tissue distribution of human guanylin. F.J.de Sauvage et al., Proc. Natl. Acad. Sci. USA, 89, 9089 (1992) |