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(Gly1,Ser3.22,Gln4.34,Thr6,Arg19,Tyr21,Ala23.31,Aib32)-Pancreatic Polypeptide (human)

CAS No.: 313988-89-5

(Gly1,Ser3.22,Gln4.34,Thr6,Arg19,Tyr21,Ala23.31,Aib32)-Pancreatic Polypeptide (human) also called (Gly1,Gln4.16,Thr6.13,
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CAS 313988-89-5
Sequence H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2
Sequence Single GPSQPTYPGDNATPEQMARYYSALRRYINMA-Aib-YQYR-NH2
Molecular Formula C183H281N57O54S2
Molecular Weight 4207.73
Synonyms (Gly1,Gln4.16,Thr6.13,Tyr7,Asp10,Asn11,Pro14,Arg26,Met30,Ala31,Aib32)-Neuropeptide Y (human, rat)
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Obesity Research
Description (Gly1,Ser3.22,Gln4.34,Thr6,Arg19,Tyr21,Ala23.31,Aib32)-Pancreatic Polypeptide (human) also called (Gly1,Gln4.16,Thr6.13,Tyr7,Asp10,Asn11,Pro14,Arg26,Met30,Ala31,Aib32)-Neuropeptide Y (human, rat), is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. (Gly1,Ser3.22,Gln4.34,Thr6,Arg19,Tyr21,Ala23.31,Aib32)-Pancreatic Polypeptide (human) induces a high amount of food intake.
References 1.  The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. C Cabrele , et al. J Biol Chem. 2000 Nov 17;275(46):36043-8.