| CAS | 258279-04-8 |
| Sequence | H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH |
| Sequence Single | GSS(octanoyl)PLSPEHQRVQQRKESKKPPAKLQPR |
| Molecular Formula | C149H249N47O42 |
| Molecular Weight | 3370.91 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Diabetes|Obesity Research |
| Description | Ghrelin (human) (GHR), the endogenous ligand of the growth hormone secretagogue receptor (GHS-R), potently stimulates GH release. The Ser3 octanoyl ester turned out to be essential for generating this activity. Ghrelin plays an important role in the short-time regulation of appetite and in the long-time regulation of energy balance and glucose homeostasis. A number of studies showed that ghrelin is also involved in the regulation of gastrointestinal, cardiovascular, and immune functions as well as in bone metabolism. |
| References | 1. Ghrelin directly regulates bone formation. N.Fukushima et al., J. Bone Miner. Res., 20, 790 (2005) 2. Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer. A.H.Yeh et al., Clin. Cancer Res., 11, 8295 (2005) 3. Ghrelin--not just another stomach hormone. G.Wang et al., Regul. Pept., 105, 75 (2002) 4. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. M.Lutter et al., Nat. Neurosci., 11, 752 (2008) |