| CAS | 141801-26-5 |
| Sequence | H-Tyr-Pro-Phe-Phe-NH2 |
| Sequence Single | YPFF-NH2 |
| Molecular Formula | C32H37N5O5 |
| Molecular Weight | 571.68 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease|Opioid Research |
| Description | Endomorphin-2 (YPFF-amide) shows, as endomorphin-1, the highest affinity and specificity for the μ-opioid receptor found so far in the mammalian nervous system, it displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. It has potent μ-selective bioactivity, including analgesia. Szegedi et al. showed that endomorphin-2 protects against Aβ 1-42 in vitro and in vivo. Acylated endomorphin-2 is used as cosmetic ingredient for sensitive skin care. |
| References | 1. Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Chapman et al (1997). Br.J.Pharmacol. 122 1537 PMID: 9422796 2. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. Goldberg et al (1998). J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962 3. Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Harrison et al (1998). Peptides 19 749 PMID: 9622031 4. A potent and selective endogenous agonist for the μ-opiate receptor. Zadina et al (1997). Nature 386 499 PMID: 9087409 5. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. Goldberg IE, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13. |