| CAS | 251634-21-6 |
| Sequence | H-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-OH |
| Sequence Single | QVPSRPNRAP |
| Molecular Formula | C47H80N18O14 |
| Molecular Weight | 1121.26 |
| Synonyms | P4 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Dynamin inhibitory peptide also called P4, is a peptide inhibitor of the GTPase dynamin. Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Dynamin inhibitory peptide reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors. |
| References | 1. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. Grabs et al (1997). J.Biol.Chem. 272 13419 PMID: 9148966 2. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. Kittler et al (2000). J.Neurosci. 20 7972 PMID: 11050117 3. Glycine binding primes NMDA receptor internalization. Nong et al (2003). Nature 422 302 PMID: 12646920 4. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. Guojun Chen, et al. J Neurosci. 2006 Mar 1;26(9):2513-21. |