| CAS | 150242-29-8 |
| Sequence | H-DL-Isoser-Phe-Leu-Leu-Arg-Asn-OH |
| Sequence Single | DL-Isoser-FLLRN |
| Molecular Formula | C34H56N10O9 |
| Molecular Weight | 748.88 |
| Synonyms | iso-TRAP, (DL-Isoser1)-Thrombin Receptor Activator Peptide 6, (DL-Isoser1)-PAR-1 (1-6) (human), (DL-Isoser1)-Proteinase Activated Receptor 1 (1-6) (human), (DL-Isoser1)-Thrombin Receptor 1 (1-6) (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology |
| Description | (DL-Isoser1)-TRAP-6 also called iso-TRAP, (DL-Isoser1)-Thrombin Receptor Activator Peptide 6, (DL-Isoser1)-PAR-1 (1-6) (human), (DL-Isoser1)-Proteinase Activated Receptor 1 (1-6) (human), (DL-Isoser1)-Thrombin Receptor 1 (1-6) (human), is a racemic isoserine analog of SFLLRN, it has only 15-20% of the platelet aggregating activity of SFLLRN. In compensation (DL-Isoser1)-TRAP-6 significantly resists degradation by aminopeptidase M and is much more stable in plasma and serum. |
| References | 1. Effects of D-amino acid substituents on degradation of LHRH analogues by proximal tubule. G.Flouret et al., Am. J. Physiol., 252, E320 (1987) 2. Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation. B.S.Coller et al., J. Biol. Chem., 268, 20741 (1993) |