| CAS | 148029-26-9 |
| Sequence | Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt |
| Sequence Single | Pyr-HWSYaLRP-NHEt |
| Molecular Formula | C56H78N16O12 |
| Molecular Weight | 1167.34 |
| Synonyms | Alarelin, Dalarelin, Surfagon, AY 25205, [DAla6, Des-Gly10] LH-RH, Ethyl Amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones|Veterinary Medicine |
| Description | (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH also called Alarelin, Dalarelin, Surfagon, AY 25205, [DAla6, Des-Gly10] LH-RH, Ethyl Amide, is a potent LHRH analog in rats and mice. Alarelin reversibly delays sexual maturation in rats. Applied as single drug or in combination with a dopamin receptor antagonist as domperidone for the stimulation and synchronization of ovulation and spawning in fish farming. CAS Number (net): 79561-22-1. |
| References | 1. Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates. K.Morihara et al., Arch. Biochem. Biophys., 165, 72 (1974) 2. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats. L.Chen et al., World J. Gastroenterol., 10, 1780 (2004) 3. The anti-reproductive pharmacology of LH-RH and agonistic analogues. A.Corbin et al., Infect. Fertil., 23, 81 (1978) 4. Androgen and progestogen production by prepubertal rat interstitial cells: study of the effects of LHRH and its analogues and their interactions with LH. G.Verhoeven and J.Cailleau, Mol. Cell. Endocrinol., 34, 7 (1984) 5. D-Ala6-des-Gly10-gonadotropin-releasing hormone ethylamide: absence of binding sites and lack of a direct effect in rabbit corpora lutea. E.U.Baitlesov et al., Russ. Agric. Sci., 33, 260 (2007) 6. Sustained release and biological availability of dalarelin from the biodegradable coacervate microcapsules. J.A.Thorson et al., Biol. Reprod., 32, 226 (1985) 7. Chronic treatment with [D-Ala6, des Gly-NH2(10)]-LHRH ethylamide reversibly delays puberty in the female rat. F.Ryszka et al., Farmaco, 57, 985 (2002) 8. Insensitivity of bonnet monkeys to (D-Ala6, Des-Gly10) LHRH ethylamide, a potent new luteinizing hormone releasing hormone analogue in rats and mice. K.M.Landymore and M.Wilkinson, Can. J. Physiol. Pharmacol., 62, 853 (1984) 9. Gonadotrophin releasing hormone analogues. D.Levitan et al., Endocrinology, 100, 918 (1977) |
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH
CAS No.: 148029-26-9
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH also called Alarelin, Dalarelin, Surfagon, AY 25205, [DAla6, Des-Gly10] LH-RH, Ethyl A
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