| CAS | 42061-33-6 |
| Sequence | 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond) |
| Sequence Single | 3-Mercaptopropionyl-YFLNCPKG-NH2 |
| Molecular Formula | C47H67N11O11S2 |
| Molecular Weight | 1026.25 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | (Deamino-Cys1,Leu4,Lys8)-Vasopressin is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. (Deamino-Cys1,Leu4,Lys8)-Vasopressin has weak antidiuretic, vasopressor, and in vitro oxytocic activities. |
| References | 1. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Ana P, et, al. Endocrinology. 2007 Sep; 148(9): 4136-46. 2. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. Ana P, et, al. J Med Chem. 2007 Feb 22; 50(4): 835-47. |
(Deamino-Cys1,Leu4,Lys8)-Vasopressin
CAS No.: 42061-33-6
(Deamino-Cys1,Leu4,Lys8)-Vasopressin is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 n
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