(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin Oxytocin, Vasotocin and Analogs Catalog

CAS	90779-69-4
Sequence	3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)
Sequence Single	3-Mercaptopropionyl-y(Et)-ITNCP-Orn-G-NH2 (Disulfide bond)
Molecular Formula	C43H67N11O12S2
Molecular Weight	994.2
Synonyms	Atosiban, RWJ 22164
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cardiovascular System & Diseases\|Pituitary & Hypothalamic Hormones
Description	(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin also called Atosiban, RWJ 22164, is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.
References	1. Phase behavior studies of quaternary systems containing N-lauroyl-N-methylglucamide/alcohol/alkane/water. X.-D.Yang et al., J. Colloid Interphase Sci., 320, 283 (2008) 2. Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea. M.Akerlund, Prog. Brain Res., 139, 359 (2002) 3. The oxytocin receptor. H.H.Zingg and S.A.Laporte, Trends Endocrinol. Metab., 14, 222 (2003) 4. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Sanu O, et al. Ther Clin Risk Manag. 2010 Apr 26;6:191-9. 5. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Philip J Ryan, et al. Nat Neurosci. 2017 Dec;20(12):1722-1733.

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