| CAS | 77327-45-8 |
| Sequence | β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond) |
| Sequence Single | β-Mercapto-β,β-cyclopentamethylene-propionyl-Y(Me)-IQNCP-Orn-G-NH2(Disulfide bond) |
| Molecular Formula | C48H74N12O12S2 |
| Molecular Weight | 1075.32 |
| Synonyms | [Pmp1, Tyr(OMe)2, Orn8] Vasotocin |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | (d(CH2)5¹,Tyr(Me)2,Orn8)-Oxytocin also called [Pmp1, Tyr(OMe)2, Orn8] Vasotocin, is a potent oxytocin antagonist with a pA2 value of 7.35 ± 0.08. (d(CH2)5¹,Tyr(Me)2,Orn8)-Vasotocin has been used to support the hypothesis that pituitary secretion of oxytocin is associated with coactivation of centrally projecting brain oxytocin pathways, some of which are causally related to the induced inhibition of food intake. Furthermore, this compound competitively inhibited arginine vasotocin (AVT) contractions without affecting AVT efficacy. |
| References | 1. Osteocalcin: the vitamin K-dependent Ca2+-binding protein of bone matrix. P.V.Hauschka, Haemostasis, 16, 258 (1986) 2. Pharmacological characterization of arginine vasotocin vascular smooth muscle receptors in the trout (Oncorhynchus mykiss) in vitro. D.J.Conklin et al., Gen. Comp. Endocrinol., 114, 36 (1999) 3. Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake. B.R.Olson et al., Endocrinology, 129, 785 (1991) |
(d(CH2)5¹,Tyr(Me)2,Orn8)-Oxytocin
CAS No.: 77327-45-8
(d(CH2)5¹,Tyr(Me)2,Orn8)-Oxytocin also called [Pmp1, Tyr(OMe)2, Orn8] Vasotocin, is a potent oxytocin antagonist with a
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