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DABCYL-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS

CAS No.: 142988-22-5

DABCYL-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS is a fluorogenic peptide substrate, it has been developed to
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CAS 142988-22-5
Sequence DABCYL-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS
Sequence Single DABCYL-Abu-HPFHLVIHT-EDANS
Molecular Formula C90H120N22O16S
Molecular Weight 1798.15
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Cardiovascular System & Diseases
Description DABCYL-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS is a fluorogenic peptide substrate, it has been developed to continuously measure the proteolytic activity of human renin (Km = 1.5 µM at physiological pH). Cleavage of the FRET substrate occurs specifically at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen. By means of this assay as low as 30 ng/mL renin can be detected after an incubation of only 3-5 min.