(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) pTH and pTH-Related Protein Catalog

CAS	118102-98-0
Sequence	H-Phe-Met-His-Asn-Leu-D-Trp-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2
Sequence Single	FMHNLwKHLSSMERVEWLRKKLQDVHNY-NH2
Molecular Formula	C165H251N49O40S2
Molecular Weight	3625.25
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
References	1. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. E.Schipani et al., Endocrinology, 132, 2157 (1993) 2. A new highly potent parathyroid hormone antagonist: [D-Trp12,Tyr34]bPTH-(7-34)NH2. A new highly potent parathyroid hormone antagonist: [D-Trp12,Tyr34]bPTH-(7-34)NH2. 3. Inhibition by (D-Trp12,Tyr34)bPTH(7-34)amide of PTH and PTHrP effects on Pi transport in renal cells. Pizurki L, et, al. Am J Physiol. 1990 Aug; 259(2 Pt 2): F389-92. 4. Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy. Kukreja SC. Endocrinology. 1994 May; 134(5): 2184-8.

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