| CAS | 193829-96-8 |
| Sequence | H-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: 2-13) |
| Sequence Single | PCKNFFWKTFSSCK (Disulfide bridge: 2-13) |
| Molecular Formula | C81H113N19O19S2 |
| Molecular Weight | 1721.03 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. |
| References | 1. Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. Deghenghi et al (2001). J.Endocrinol.Invest. 24 RC1 PMID: 11227737 2. Pharmacology and signaling of MAS-related G protein-coupled receptors. Solinski et al (2014). Pharmacol.Rev. 66 570 PMID: 24867890 |