| Sequence | H-Leu-Ala-Ser-Glu-Ser-Thr-His-Glu-Asp-Arg-Asn-Val-Glu-His-Met-Ala-Glu-Val-His-Ile-OH |
| Sequence Single | LASESTHEDRNVEHMAEVHI |
| Molecular Formula | C95H150N30O35S |
| Molecular Weight | 2304.48 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | HDAC1 plays an important role in modulating the eukaryotic chromatin structure and was found to interact specifically in yeast, mammalian cells, and in vitro with the human Hus1 gene product, as reported by Cai and coworkers. The Hus1 protein of S. pombe has been implicated in G2/M checkpoint control and is a member of the cell cycle checkpoint Rad proteins that are involved in the mitotic checkpoint induced by either DNA damage or DNA replication block. |
| References | 1. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. J.Liu et al., Mol. Cell, 10, 1511 (2002) |
Checkpoint Protein Hus1 (213-232) (human)
CAS No.:
HDAC1 plays an important role in modulating the eukaryotic chromatin structure and was found to interact specifically in
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