| CAS | 851538-67-5 |
| Sequence | H-Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp-OH |
| Sequence Single | TDSGFCLDSPGPLD |
| Molecular Formula | C60H90N14O24S |
| Molecular Weight | 1423.52 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | The abundance of Cdc25A fluctuates periodically during the cell division cycle, which is primarily modulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, Anaphase Promoting Complex/Cyclosome and Skp1/Cul1/F-box protein. Ubiquitylation and degradation occurs at mitotic exit and in G1 due to the presence of a destruction motif (KEN-box) in Cdc25A, while phosphorylation events regulate Cdc25A protein stability in S phase both in unperturbed cells and in cells exposed to DNA damaging agents or DNA replication inhibitors. |
| References | 1. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. M.Melixetian et al., Nat. Cell Biol., 11, 1274 (2009) 2. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. L.Busino et al., Nature, 426, 87 (2003) |