| CAS | 37025-55-1 |
| Sequence | Butyryl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Sulfide bond between Butyryl-4-yl and Cys) |
| Sequence Single | Butyryl-Y(Me)-IQNCPLG-NH2 (Sulfide bond between Butyryl-4-yl and Cys) |
| Molecular Formula | C45H69N11O12S |
| Molecular Weight | 988.18 |
| Synonyms | (Butyryl1,Tyr(Me)2)-Oxytocin, (Butyryl1,Tyr(Me)2)-1-Carbaoxytocin |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Veterinary Medicine |
| Description | Carbetocin also called (Butyryl1,Tyr(Me)2)-Oxytocin, (Butyryl1,Tyr(Me)2)-1-Carbaoxytocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS. |
| References | 1. Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. Y.Itoh et al., FEBS Lett., 231, 440 (1988) 2. Effect of oxytocin and its long-acting analog on milk let-down and intramammary pressure in healthy lactating sows. N.Cort et al., Am. J. Vet. Res., 43, 1283 (1982) 3. Prevention of postpartum haemorrhage with the oxytocin analogue carbetocin. W.Rath, Eur. J. Obstet. Gynecol. Reprod. Biol., 147, 15 (2009) 4. The effect of some structural modifications of the oxytocin molecule on the duration of the galactogogic response. T.Barth et al., Coll. Czech. Chem. Commun., 46, 2441 (1981) 5. Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Stella Chaviaras, et al. Psychopharmacology (Berl). 2010 May;210(1):35-43. 6. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Gerald Gimpl, et al. Eur J Pharmacol. 2005 Mar 7;510(1-2):9-16. 1. The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating. David Feifel, et al. Eur Neuropsychopharmacol. 2012 May;22(5):374-8. |