cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat) Protein Kinase Related Peptides Catalog

CAS	100853-58-5
Sequence	H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Sequence Single	TTYADFIASGRTGRRNAI-NH2
Molecular Formula	C84H137N29O26
Molecular Weight	1969.19
Synonyms	PKI-α (5-22) amide (human, mouse, rabbit, rat), Wiptide, cAMP Dependent PK Inhibitor (5-22), amide
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat) also called PKI-α (5-22) amide (human, mouse, rabbit, rat), Wiptide, cAMP Dependent PK Inhibitor (5-22), amide, is the active inhibitory fragment of the inhibitor of the cAMP-dependent protein kinase (PKA). It is a cAMP-dependent protein kinase inhibitor. cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors.
References	1. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Dautzenberg FM, et al. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. 2. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Reed J, et al. Biochem J. 1989 Dec 1;264(2):371-80.

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