C-Type Natriuretic Peptide (32-53) (human, porcine, rat) Natriuretic Peptides Catalog

CAS	127869-51-6
Sequence	H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-OH (Disulfide bond)
Sequence Single	GLSKGCFGLKLDRIGSMSGLGC
Molecular Formula	C93H157N27O28S3
Molecular Weight	2197.63
Synonyms	CNP-22 (human, porcine, rat), C-Type Natriuretic Peptide (32-53), human
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cardiovascular System & Diseases
Description	C-Type Natriuretic Peptide (32-53) (human, porcine, rat) also called CNP-22 (human, porcine, rat), C-Type Natriuretic Peptide (32-53), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (32-53) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor.
References	1. Effects of L-glutamate, substance P and substance P(1-7) on cardiovascular regulation in the nucleus tractus solitarius. M.E.Hall et al., Regul. Pept., 46, 102 (1993) 2. Urinary C-Type Natriuretic Peptide: A New Heart Failure Biomarker. R.Zakeri et al., JACC: Heart Failure, 1, 170 (2013) 3. ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. Morozumi N, et al. PLoS One. 2019 Feb 22;14(2):e0212680. 4. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Buckley MG, et al. Clin Sci (Lond). 2000 Nov;99(5):467-72. 5. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Mazarati AM, et al. Life Sci. 1993;52(3):PL19-24.

PeptideDB

C-Type Natriuretic Peptide (32-53) (human, porcine, rat)

CAS No.: 127869-51-6