| CAS | 159013-54-4 |
| Sequence | Diphenylacetyl-D-Arg-4-hydroxybenzylamide |
| Sequence Single | Diphenylacetyl-r-4-hydroxybenzylamide |
| Molecular Formula | C27H31N5O3 |
| Molecular Weight | 473.58 |
| Synonyms | BIBP 3226 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Obesity Research |
| Description | BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect. BIBP3226 also reduced the NPY-induced increase in intracellular calcium as well as the pressor response in vitro and in vivo. BIBP3226 inhibited NPY induced feeding in rats. In dogs, intra-arterial infusion of BIBP-3226 interrupted tonic NPY Y1 receptor-mediated vasoconstriction in exercising skeletal muscle, resulting in substantial increases in experimental limb blood flow. CAS-Number (acetate): 1068148-47-9. |
| References | 1. Differential effects of parathyroid hormone fragments on collagen gene expression in chondrocytes. S.Erdmann et al., J. Cell Biol., 135, 1179 (1996) 2. Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family. C.Cabrele and A.G.Beck-Sickinger, J. Pept. Sci., 6, 97 (2000) 3. Neuropeptide Y1 receptor vasoconstriction in exercising canine skeletal muscles. J.B.Buckwalter et al., J. Appl. Physiol., 99, 2115 (2005) 4. The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. K.Rudolf et al., Eur. J. Pharmacol., 271, R11 (1994) 5. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Mollereau C, et al. Br J Pharmacol. 2001 May;133(1):1-4. |