(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, Natriuretic Peptides Catalog

CAS	132956-87-7
Sequence	H-Arg-Cys-β-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 (Disulfide bond)
Sequence Single	H-RC-β-cyclohexyl-AGGRIDRIe-D-Tic-RC-NH2 (Disulfide bond)
Molecular Formula	C69H116N26O15S2
Molecular Weight	1613.98
Synonyms	A71915
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cardiovascular System & Diseases
Description	(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) also called A71915, is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
References	1. Physiological role of silent receptors of atrial natriuretic factor. T.Maack et al., Science, 238, 675 (1987) 2. Atrial natriuretic peptide antagonists: biological evaluation and structural correlations. T.W.von Geldern et al., Mol. Pharmacol., 38, 771 (1990) 3. Atrial natriuretic factor increases splenic microvascular pressure and fluid extravasation in the rat. R.Sultanian et al., J. Physiol., 533, 273 (2001) 4. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Delporte C, et al. Eur J Pharmacol. 1992;224(2-3):183-188. 5. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. Kiguchi N, et al. 6. Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. Park BM, et al. Peptides. 2015;69:1-8.

PeptideDB

(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit,

CAS No.: 132956-87-7