| CAS | 122604-16-4 |
| Sequence | H-Asp-Thr-Ala-Ser-Asp-Ala-Ala-Ala-Ala-Ala-Ala-Leu-Thr-Ala-Ala-Asn-Ala-Lys-Ala-Ala-Ala-Glu-Leu-Thr-Ala-Ala-Asn-Ala-Ala-Ala-Ala-Ala-Ala-Ala-Thr-Ala-Arg-OH |
| Sequence Single | DTASDAAAAAALTAANAKAAAELTAANAAAAAAATAR |
| Molecular Formula | C133H225N43O51 |
| Molecular Weight | 3242.47 |
| Synonyms | AFP 6 (winter flounder), HPLC 6 (winter flounder) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Antifreeze Polypeptide 6 (winter flounder) also called AFP 6 (winter flounder), HPLC 6 (winter flounder), have in common the ability to lower the freezing point of blood serum, thus allowing fish to survive in subzero ocean temperatures. The type I AFPs are present in the blood of winter flounder, yellowtail flounder, Alaskan plaice and the shorthorn and grubby sculpin. Antifreeze Polypeptide 6 (winter flounder) isolated from the winter flounder, Pseudopleuronectes americanus, consists of 37 amino acids arranged in three 11-residue repeats which tend to form α-helices. |
| References | 1. Caloxin: a novel plasma membrane Ca2+ pump inhibitor. Caloxin: a novel plasma membrane Ca2+ pump inhibitor. J.Chaudhary et al., Am. J. Physiol., Cell Physiol., 280, C1027 (2001) 2. Increased flexibility decreases antifreeze protein activity. S.N.Patel and S.P.Graether, Protein Sci., 19, 2356 (2010) 3. A model for binding of an antifreeze polypeptide to ice. A model for binding of an antifreeze polypeptide to ice. |
Antifreeze Polypeptide 6 (winter flounder)
CAS No.: 122604-16-4
Antifreeze Polypeptide 6 (winter flounder) also called AFP 6 (winter flounder), HPLC 6 (winter flounder), have in common
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