| CAS | 581-05-5 |
| Sequence | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Sequence Single | Ac-SYSMEHFRWGKPV-NH2 |
| Molecular Formula | C77H109N21O19S |
| Molecular Weight | 1664.91 |
| Synonyms | Acetyl-ACTH (1-13) amide, α-Melanotropin (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | α-MSH also known as α-melanocyte-stimulating hormone (α-MSH), Acetyl-ACTH (1-13) amide, α-Melanotropin (human), is a 13-amino acid peptide originally characterized as a neuropeptide derived from the pituitary gland. α-MSH is synthesized from pro-opiomelanocortin (POMC) by the action of specific prohormone convertases and is involved in the regulation of important physiological functions including food intake, energy homeostasis, modulation of immune responses and photoprotection. α-MSH is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. |
| References | 1. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Madhuri Singh, et al. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. 2. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. M S Kim, et al. Diabetes. 2000 Feb;49(2):177-82. 3. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Lipton JM, et al. Ann N Y Acad Sci. 1999;885:173-182. |