| CAS | 10466-28-1 |
| Sequence | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-OH |
| Sequence Single | Ac-SYSMEHFRWGKPV |
| Molecular Formula | C77H108N20O20S |
| Molecular Weight | 1665.89 |
| Synonyms | Acetyl-ACTH (1-13) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | α-MSH (free acid) also called Acetyl-ACTH (1-13), α-Melanocyte-Stimulating Hormone free acid, is an MC3R and MC4R agonist with EC50s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R. |
| References | 1. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. Miwa H, et al. J Pharmacol Exp Ther. 1995;273(1):367-372. |