| CAS | 121062-08-6 |
| Sequence | Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys-NH2) |
| Sequence Single | Ac-Nle-cyclo(-DHfRWK-NH2) |
| Molecular Formula | C50H69N15O9 |
| Molecular Weight | 1024.19 |
| Synonyms | MTII, Melanotan II, Bremelanotide amide, (Ac-Nle4, Asp5, DPhe7, Lys10)-Cyclo-a-MSH (4-10) amide, MT-II |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Cosmetic Peptides & Dermatology|Obesity Research|Pituitary & Hypothalamic Hormones |
| Description | Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) amide also called MTII, Melanotan II, Bremelanotide amide, (Ac-Nle4, Asp5, DPhe7, Lys10)-Cyclo-a-MSH (4-10) amide, MT-II, a cyclic MSH analog, is a potent full agonist of the melanocortin-3 and melanocortin-4 receptors (MC3-R and MC4-R). Intracerebroventricular administration of Melanotan II inhibited feeding in four different mouse models of hyperphagia. Melanotan II is a valuable tool for the study of the agouti obesity syndrome and of the role of melanocortinergic neurons in feeding. |
| References | 1. Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor. C.Gründker et al., Eur. J. Endocrinol., 151, 141 (2004) 2. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. V.J.Hruby et al., J. Med. Chem., 38, 3454 (1995) 3. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. W.Fan et al., Nature, 385, 165 (1997) 4. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. V.J.Hruby et al., J. Med. Chem., 38, 3454 (1995) 5. Identification and characterization by LC-UV-MS/MS of melanotan II skin-tanning products sold illegally on the Internet. Breindahl T, et al. Drug Test Anal. 2015 Feb;7(2):164-72. 6. Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. Giuliano F, et al. Neuroscience. 2006;138(1):293-301. |
Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) amide
CAS No.: 121062-08-6
Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) amide also called MTII, Melanotan II, Bremelanotide amide, (Ac-Nle4,
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