| CAS | 819048-44-7 |
| Sequence | Ac-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2 (Disulfide bond) |
| Sequence Single | Ac-rCEHfRWC-NH2 |
| Molecular Formula | C51H70N18O11S2 |
| Molecular Weight | 1175.36 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research|Pituitary & Hypothalamic Hormones |
| Description | Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide is a highly potent and selective β-MSH-derived melanocortin-4 receptor (MC-4R) agonist with sub-nanomolar potency. The binding affinities for human MC-4R, MC-1R, MC-3R and MC-5R were 0.55 ± 0.06, 16.78 ± 1.53, 56.79 ± 4.66, and < 500 nM, respectively. Daily subcutaneous injection of this product to diet-induced obese rats over a period of 14 days demonstrated an effect on reduction of fat mass. |
| References | 1. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. H.Hosoda et al., Biochem. Biophys. Res. Commun., 279, 909 (2000) |
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide
CAS No.: 819048-44-7
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide is a highly potent and selective β-MSH-derived melanocortin-4
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