Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide Melanocyte-Stimulating Hormone Catalog

CAS	207678-81-7
Sequence	Ac-Cys-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond)
Sequence Single	Ac-CEH-D-2-Nal-RWGCPPKD-NH2(Disulfide bond)
Molecular Formula	C71H94N20O17S2
Molecular Weight	1563.78
Synonyms	HS014
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Obesity Research\|Pituitary & Hypothalamic Hormones
Description	Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide also called HS014, is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats. HS014 appears to be a useful tool to investigate the physiology of the MC4 receptor.
References	1. Discovery of novel melanocortin4 receptor selective MSH analogues. Schiöth HB,et al. Br J Pharmacol. 1998;124(1):75-82. 2. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Ercil NE, et al. Psychopharmacology (Berl). 2005;180(2):279-285. 3. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Kask A, et al. Biochem Biophys Res Commun. 1998;245(1):90-93.

PeptideDB