Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt Matrix Metalloproteinase Catalog

CAS	98992-65-5
Sequence	Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Sequence Single	Ac-PLG[(S)-2-mercapto-4-methyl-pentanoyl]LG-OEt
Molecular Formula	C31H53N5O8S
Molecular Weight	655.86
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cancer Research\|Inflammation Research
Description	The thiopeptolide Ac-Pro-Leu-Gly-psi[COS]Leu-Leu-Gly-OEt is used as substrate in a rapid, sensitive, continuous spectrophotometric assay for vertebrate collagenase, gelatinase A, and gelatinase B. Besides the mercaptan to be determined, cleavage yields Ac-PLG.
References	1. The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH. H.B.Schiöth et al., J. Endocrinol. , 155, 73 (1997) 2. Comparison of cleavage site specificity of gelatinases A and B using collagenous peptides. T.Xia et al., Biochim. Biophys. Acta, 1293, 259 (1996) 3. Synthetic substrates of vertebrate collagenase. H.Weingarten et al., Biochemistry, 24, 6730 (1985) 4. Spectrophotometric assay for vertebrate collagenase. H.Weingarten and J.Feder, Anal. Biochem., 147, 437 (1985)

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