| CAS | 208255-51-0 |
| Sequence | 3,5-Difluorophenylacetyl-Ala-Phg-OMe |
| Sequence Single | 3,5-Difluorophenylacetyl-A-Phg-OMe |
| Molecular Formula | C20H20F2N2O4 |
| Molecular Weight | 390.39 |
| Synonyms | DAPM |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | 3,5-Difluorophenylacetyl-Ala-Phg-OMe also called DAPM, a cell-permeable γ-secretase inhibitor with anti-aggregation properties that dose-dependently inhibits amyloid β-protein (Aβ) secretion in 7PA2 Chinese hamster ovary (CHO) cells with an half-maximal inhibitory concentration of IC50 ~ 10 nM. DAPM prevents oligomer formation by selectively blocking the Aβ dimer and trimer formation at doses that allow appreciable monomer production. |
3,5-Difluorophenylacetyl-Ala-Phg-OMe
CAS No.: 208255-51-0
3,5-Difluorophenylacetyl-Ala-Phg-OMe also called DAPM, a cell-permeable γ-secretase inhibitor with anti-aggregation pro
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