smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). smMLCK peptide inhibits kinase activity by mimicking the substrate and competitively inhibiting the binding of the actual substrate to the enzyme. This inhibition prevents the phosphorylation of myosin light chain, thereby inhibiting muscle contraction.

Physicochemical Properties

Molecular Formula	C98H168N38O25
Molecular Weight	2278.62
CAS #	172960-20-2
SMILES	C(O)(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N
Synonyms	Smooth-Muscle Myosin Light-Chain Kinase (796-815)
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Relative Cosolute Size Influences the Kinetics of Protein-Protein Interactions. Biophys J. 2015 Aug 4;109(3):510-20.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.4389 mL	2.1943 mL	4.3886 mL
	5 mM	0.0878 mL	0.4389 mL	0.8777 mL
	10 mM	0.0439 mL	0.2194 mL	0.4389 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.